The VAMP2 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to Synaptobrevin 2, and VAMP-2. This antibody recognizes Human, Mouse, and Rat antigen. The VAMP2 Antibody has been validated for the following applications: Immunohistochemistry, and Western Blot.
Description
Vesicle-associated membrane protein 2 (VAMP2, also called synaptobrevin) is part of the R-soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex (1). The SNARE complex is involved in vesicular transport and membrane fusion, a process regulated by calcium (2). In neurons, VAMP2 is predominantly inserted in presynaptic vesicle membranes. Assembly of VAMP2 with the plasma membrane SNAREs syntaxin 1 and SNAP25 is a key event necessary for membrane fusion and neurotransmitter release (2). In addition to this important function, VAMP2 is also involved in granule exocytosis in neutrophils (3) and release of bioactive peptides from cardiac myocytes (4) and juxtaglomerular cells (5)